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Thesis work: CFD simulation to predict deposition, Gothenburg

Publicerad 2022-11-16

Thesis work: CFD simulation to predict the deposition of inhaled medicines in human lungs

If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us!

Thesis type: 30 credits
Project start: January 2023
Student location: On Site, Gothenburg Sweden

A unique opportunity for a master thesis 

Are you currently pursuing a master’s degree with a burning interest in pharmaceutical development and computation fluid dynamics? This master’s thesis project at AstraZeneca might be of interest to you!

At AstraZeneca Gothenburg, one of the focus areas is to develop medicines for the treatment of respiratory diseases e.g. asthma, COPD using pulmonary drug delivery technology. For this route, the deposition e.g. pattern and concentration, of drug particles at targeted areas in human lung is critical to the effectiveness of medicines. 

The ultimate goal of this thesis is to investigate and quantitatively map the influence of critical attributes of medicines and patient profiles to drug deposition. 

At AstraZeneca, all of our employees make a difference to patients’ lives every day. We operate in more than 100 countries around the world and are one of Sweden’s most important export companies.
 
With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca’s three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.

qualifications.

Essential Requirements 
  • Interest in pharmaceutical development
  • Experience and interest in computational fluid dynamics
  • Solid understanding in transport phenomena and mathematical modelling
  • Excellent problem solving, communication skills  
  • Pursuing a master’s degree in a relevant engineering discipline

Desirable Requirements 
  • Skills in computer programming e.g. C++, python

responsibilities.

This thesis aims to develop CFD models towards an alternative tool to in-vivo and in-vitro methods in order to predict local deposition of drug particles in human lung.

Responsibilities include:

  • Developing and optimising CFD models for lung deposition on a realistic 3D geometry of human lung
  • Parametric study of lung deposition using the developed CFD models
  • Validating simulation results with available experimental data

The work is to be conducted from January to June 2023, or as agreed with the student.

Liknande jobb:

Publicerad: 2022-11-21
  • Gothenburg
  • Göteborg